Lately I have seen lots of interest in WordPress, so I've been investigating it for use in creating a website quickly that can be easily modified. This post discusses using Dreamweaver vs. WordPress as of this date. My ideas will probably change next week...
If you are comfortable with Dreamweaver and your content doesn't change a lot, you can find a template on the web that you can download and modify as you like (see http://www.freewebsitetemplates.com/ for example). It's best if the template incorporates Photoshop pages (.psd format) so you can customize the graphics. The problem with proceeding this way is that you will either be the main person changing content, or you will need to tie into a database for content management which you can do through a tool such as PHP. The advantage of going this way is that you can create a static, search-optimized site fairly easily, especially by using a Dreamweaver template.
Wordpress seems to be on the rise, for several reasons. First, it's a hosted solution and doesn't necessarily require expensive and complicated tools such as Dreamweaver and Photoshop to make changes to a site (unless you want to customize look and feel). It can be set up so anyone with a login can change the look and feel. It's also free and open source. Also, as you may have noticed, there are thousands of themes available and a huge community of online support. The downsides: you will need a host that supports it and can run PHP, usually on a Linux server. Also, it helps to know PHP although they say it's not necessary.
The best place to start with Wordpress is on the website http://codex.wordpress.org/Main_Page. There actually is a link here http://codex.wordpress.org/Getting_Started_with_WordPress.